Redes genéticas sintéticas: De lo simple a lo complejo.

Alexandre Wagemakers, Miguel A. Fernández Sanjuán, Javier M. Buldú, Oscar de Luis, Antonio Coloma


The cells are systems with a great complexity due to the existing high number of interactions of diverse nature between their numerous components, particularly between proteins and genes. The understanding of these interactions is of vital importance, since they are those that regulate the fundamental cellular processes. Many years of experimentation have been necessary to keep awake the molecular bases of these processes. Recently, a new complementary route for the study of the interactions between genes and proteins based on the design of synthetic genetic networks has begun. The creation of these artificial genetic networks, much more simple that those that operate in the cell, is contributing to decipher the existing relation between the coordinated activity of groups of genes and the cellular functions. This has given rise to the birth of the so-called Synthetic Biology, where Nonlinear Dynamics, Physics of Complex Systems, Engineering and Molecular Biology play an important role

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